We are proud to announce that Advanced Science has published the recent article titled "A Non-Coding Oligonucleotide Recruits Cutaneous CD11b+ Cells that Inhibit T-helper Responses and Promote Tregs." This research unveils the immunoregulatory capabilities of our oligonucleotide TIR-01, highlighting its potential as a therapeutic agent.
The study explores how TIR-01 recruits cutaneous immunoregulatory antigen-presenting cells (APCs) that exhibit enhanced expression of immune checkpoint proteins. Through detailed functional T-cell assays, the research demonstrates that these APCs effectively inhibit T-helper cell responses while promoting CD4+FoxP3+Tregs.
The findings suggest that TIR-01 holds promise as a therapeutic tool for rebalancing overactive T-helper cell responses in the skin, paving the way for new treatments in immunotherapy.
Read the full article: https://onlinelibrary.wiley.com/doi/10.1002/advs.202400260